A large new study published in the Journal of the American Medical Association demonstrated life-saving benefits of LDR brachytherapy—also known as seed implant—for men with high-grade prostate cancer.
LDR brachytherapy treatment for men with high-grade prostate cancer
Researchers at 12 specialty centers were led by Amar U. Kishan, M.D., University of California Los Angeles. They analyzed prostate cancer treatment outcomes for over 1,809 patients with Gleason scores of 9 and 10—men more likely to have their cancer spread to other organs. The study showed that men who received low dose rate (LDR) brachtherapy as a boost to external beam radiation therapy (EBRT), had better clinical outcomes than men undergoing either radical prostatectomy surgery (removal of the entire prostate gland) or EBRT alone.
Men in both external beam radiation groups also received androgen deprivation hormone therapy, which is prescribed commonly to slow the growth of cancerous tissue and/or reduce the size of the prostate gland pre-treatment.
Better outcomes with LDR brachytherapy
According to the study, adding LDR brachytherapy to EBRT resulted in less prostate cancer deaths and less spread of cancer beyond the prostate. More specifically, EBRT with seed implant resulted in lower 5-year prostate cancer-specific mortality; lower 5-year rate of distant metastasis and lower all-cause mortality within 7.5 years of follow-up, when compared to both prostate removal surgery and to EBRT alone.
Seed implant as a boost treatment for prostate cancer
At Chicago Prostate Cancer Center, combination therapy with LDR brachytherapy reflects the promising findings of the UCLA study. LDR brachytherapy is provided following prescribed sessions of external beam radiation. Placed directly inside the prostate, seed implant safely destroys cancerous tissue with one of several possible sources of ionizing radiation.
For more information about prostate cancer treatment, or to schedule a consultation, contact Chicago Prostate Cancer Center at 630-654-2515, or visit prostateimplant.com.
Chicago Prostate Cancer Center treats prostate cancer with a focus on quality of life.